Tissue engineering is a technology designed to develop biological substitutes in order to restore, maintain or improve tissue function. In the area of cosmetic and dermatological research, its purpose is to reconstruct in vitro human skin that has the physiological functions of the skin. These models have two aspects in common, namely a support for cultivating the keratinocytes and exposure of the culture to the air which induces spatial organisation and contributes to forming the horny layer. The only difference between these models is in the types of cells included, in the composition of the supports and the culture conditions.

With its know-how in the area of cutaneous tissue engineering, L’Oréal has created a multidisciplinary platform : models/prototypes are conceived of in fundamental research; development consolidates them and develops new in vitro methods; EPISKIN SNC, L’Oréal's industrial centre for cutaneous engineering, standardizes and produces the prototypes on a large scale. This tissue engineering platform thus responds to the challenges facing L’Oréal and the company’s commitments to create models which mimic the major physiological functions of the skin, develop them for specific applications and participate actively in validating alternative methods to animal testing.

A Scientific approach

The skin in 3D

The story of reconstructed skin
Reconstructing the epidermis
Epidermal model on a dermis equivalent
Why have skin models?

The TERMIS-EU L’Oréal Recherche & Innovation Awards

L’ORÉAL and HµREL® Corporation collaborate for the development of a model for contact allergy

Ending the practice of animal testing

Alternative Approaches to Animal Testing

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